Representative autoradiographic images of Hmw multimers from 1 patient with recurrent TTP (patient R12 [A]), from 1 patient with familial HUS/TTP (patient F39#3 [B]), and from 1 patient with sporadic HUS/TTP (C). The origin of the gel is at the top. (A) Lane 1, plasma from healthy control; lane 2, patient plasma collected during the acute phase; lane 3, patient plasma collected at remission. Brackets indicate the position of UL vWF multimers that are present exclusively in patients with the recurrent form, both during and between relapses. (B) Lane 1, plasma from healthy control; lane 2, patient plasma collected during the acute phase; lane 3, patient plasma collected at remission. Brackets indicate the position of Hmw multimers that are decreased in plasma samples of patients with the familial HUS/TTP both during the acute phase and at remission. (C) Lane 1, patient plasma collected during the acute phase; lane 2, patient plasma collected at remission; lane 3, plasma from healthy control. Brackets indicate the position of Hmw multimers that are decreased in patient plasma during the acute phase of the disease.