The ability of indomethicin to reverse the inhibitory effect of FDCs on sAg-induced autologous T-cell proliferation. FDCs (2 × 10⁴) were cultured with 10⁵ autologous tonsil T cells and SEB (100 ng/mL) in the presence and absence of indomethicin (100 μg/mL) for 3 days. Tritiated thymidine uptake was measured during the last 24 hours of culture. Each bar represents the mean cpm + SEM of three independent experiments and is expressed as a percentage of the response generated when T cells were cultured with only SEB. Cpm from cultures containing only T cells ranged from 1,290 to 3,939. The addition of indomethicin to cultures containing FDCs resulted in a significant increase in T-cell proliferation compared to cultures containing FDCs without indomethicin using a pairedt-test.