American Society of Hematology

Fig. 9.

$Summary of the level of human cell engraftment in the BM of 35 mice transplanted 8 weeks previously with cells deriving from ex vivo expansion cultures at weeks 9 to 10 in the presence of IL-6, SCF, FL, and MGDF. Individual NOD/SCID mice (each symbol represents a mouse) were injected with fractions of the expanded cells, corresponding to numbers of initial CD34+ cells indicated on the abscissa. The level of human engraftment in the mouse BM was evaluated by both flow cytometry and DNA analysis as described in Materials and Methods.$

Summary of the level of human cell engraftment in the BM of 35 mice transplanted 8 weeks previously with cells deriving from ex vivo expansion cultures at weeks 9 to 10 in the presence of IL-6, SCF, FL, and MGDF. Individual NOD/SCID mice (each symbol represents a mouse) were injected with fractions of the expanded cells, corresponding to numbers of initial CD34⁺ cells indicated on the abscissa. The level of human engraftment in the mouse BM was evaluated by both flow cytometry and DNA analysis as described in Materials and Methods.

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