Prothrombin fragment F1+2 generation observed on unstimulated or LPS-stimulated (0.4 ng/mL) monocytes added with and without vitamin E (50 μmol/L) and exposed to a standard heparinized overlay milieu (see text). The paired t-test was used for statistical analysis. *P = .025. The top and bottom of the box represent the standard error. The square in the middle of the box represents the mean value. The lines extending above and below the box refer to the standard deviation.