Fig. 5.
![Fig. 5. Effect of bcl-2 on Dex-mediated downregulation of κB-dependent reporter gene activity. Parental and bcl-2 ARP-1 transfectants were transiently transfected with either a TK-Luc reporter plasmid or TK-Luc reporter plasmid harboring three κB sites and subsequently cultured in the presence or absence of Dex (0.1 μmol/L) for 20 hours. The level of κB transcriptional activity is indicated as percentage control (relative light units [RLU]/μg of protein) and normalized to protein content. The average of 13 (parental ARP-1) and 12 (bcl-2 ARP-1) individual experiments is represented.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/93/9/10.1182_blood.v93.9.3044/4/blod40913005x.jpeg?Expires=1724275510&Signature=nexp-U5SC8jd~Fz9QRP1xw~5CCN41AlegCU8qogHkXFHB16RcBJBXj1s1fXyZ5TtBB6wmAoVSO0ePPqiTV9wbObhoHTkRQJA1aZOoEEZH4kcjtwyzZV2UUBqmvmLtB3Z6o1PlBtmamrOeaXbdnb0gMEOTi8JbSt1pR4Apd7DV4bHXgF9q-TluWV5nlo3hSITOQSQRvlyH6iIjQKZkO-hgX9ofg~Pm3OZOL4ypXHYvcsswbv2HzgMXJ5kMJ~eU2mhYDgaqWd4cnNrdQNQLlRHXeQBN-5jzqa7P-xWIPo0Ut378xhUaIP4mhmOrS0-YHdQg~3enz1ILXEILfN0aDgeNg__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Effect of bcl-2 on Dex-mediated downregulation of κB-dependent reporter gene activity. Parental and bcl-2 ARP-1 transfectants were transiently transfected with either a TK-Luc reporter plasmid or TK-Luc reporter plasmid harboring three κB sites and subsequently cultured in the presence or absence of Dex (0.1 μmol/L) for 20 hours. The level of κB transcriptional activity is indicated as percentage control (relative light units [RLU]/μg of protein) and normalized to protein content. The average of 13 (parental ARP-1) and 12 (bcl-2 ARP-1) individual experiments is represented.
