Biodistribution of pGCR (open bars) and rGCR (solid bars) after IV administration to Balb/c mice at doses of 40 U/kg. Control mice were injected with 1 mg/kg mannosylated BSA. Tissues were harvested 20 minutes postdose and analyzed for glucocerebrosidase activity. (A) Ratio of glucocerebrosidase activity in tissues from pGCR- and rGCR-injected animals relative to activity in tissues from mannosylated BSA-injected controls (denoted by a horizontal line). (B) Glucocerebrosidase activity recovered from individual organs as a percent of injected dose. Values presented are the averages and standard deviations of determinations made on 12 animals per treatment group.