Fig. 1.
Accumulation of total MTX, ie, MTX-Glu1-6(pmol/109 cells; left panel) and of long chain polyglutamates, ie, MTX-Glu4-6 (pmol/109 cells; right panel) in c/preB-ALL (n = 45), T-ALL (n = 15), and AML cells (n = 14) after 24 hours in vitro incubation with 1 μmol/L [3H]-MTX. Each patient sample is represented by a dot, lines represent the median values.

Accumulation of total MTX, ie, MTX-Glu1-6(pmol/109 cells; left panel) and of long chain polyglutamates, ie, MTX-Glu4-6 (pmol/109 cells; right panel) in c/preB-ALL (n = 45), T-ALL (n = 15), and AML cells (n = 14) after 24 hours in vitro incubation with 1 μmol/L [3H]-MTX. Each patient sample is represented by a dot, lines represent the median values.

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