Hematologic and iron status in response to pyridoxine supplementation and iron removal by desferrioxamine chelation and/or phlebotomy. The probands were reliable regarding pyridoxine self-administration and were in good health during the critical periods of pyridoxine administration (family 5: months 108-113 and 130-135; family 6: Months 140-145 and 160-165). Repeat blood counts were confirmatory of the observed trends. (A.) Family 5 (Y199H) proband. (B). Family 6 (R411C) proband.