Histograms showing (A) the number and (B) the area of osteolytic lesions in the long bones of 5TGM1 myeloma-bearing and control mice with and without ibandronate treatment. Lesions were quantified by computerized image analysis from radiographs taken at death. Data are mean ± SEM (n = 6). ∗, Significant reduction compared with myeloma + PBS.