Nucleotide and deduced amino acid sequence of the PTK domain of ETV6-TRKC chimeric genes detected in t(12;15)-positive AML (C-1, C-2, and C-3) and congenital fibrosarcoma (CFS). In C-2 and C-3, 3′-terminal 462 bp was truncated within the PTK domain at nucleotide position (nt) 2288 of TRKC, followed by 2 unrelated amino acids and TGA stop codon originating from the intron sequence of TRKC. The number shown above is the amino acid residue in C-1. The nucleotide and deduced amino acid sequence of the 42-bp sequence inserted in the kinase domain in CFS are also indicated. The solid box shows the tyrosine residues (YY) corresponding to the putative major autophosphorylation sites ofTRKC.