The kinetics of serum IL-8 (A), MIP-1 (B), TNF- (C), and IFN-γ (D) before and during G-CSF treatment. Each solid circle represents the value of a patient, and an open circle and bar is the mean ± standard deviation. The levels of serum IL-8 were significantly higher on days 5 and 6 of G-CSF treatment as compared with baseline and those on days 2 to 4 (P < .001). No significant change was observed in the kinetics of serum MIP-1, TNF-, or IFN-γ secretion. *P < .001.