(A) Ultrastructural features of the AML-5 cell line after 2 days of exposure to solvent control or 20 μmol/L lovastatin. (a) Control AML-5 cells; (b and c) lovastatin treatment-induced nuclear morphology changes in AML-5; (d) characteristic features of apoptosis were observed in the majority of lovastatin-treated AML-5 cells. The bar represents 1 μm. (B) Multilaser flow cytometric analysis of reduced GSH and MMP. AML-5 cells were exposed to solvent control or 20 μmol/L lovastatin for 2 days and analyzed. Dual-parameter dot plots of GSH and MMP for each sample are also presented.