American Society of Hematology

Fig. 3.

$Fig. 3. The reversibility of heparin’s effects on the percentage of cancellous bone surface length occupied by either osteoblasts or osteoid. Rats were injected daily with vehicle alone (open bars) or unfractionated heparin at a concentration of either 0.5 U/g/day (cross hatched; rising to the right) or 1.0 U/g/day (cross hatched; rising to the left). On day 28, half of the rats from each group were killed while the other half were allowed to live for an additional 28 days with no further treatment before determining the percentage of cancellous bone surface lined with either osteoblasts (A) or osteoid (B). Data are expressed as mean ± SEM. *P < .005 when compared with either baseline or control values for both (A and B).$

The reversibility of heparin’s effects on the percentage of cancellous bone surface length occupied by either osteoblasts or osteoid. Rats were injected daily with vehicle alone (open bars) or unfractionated heparin at a concentration of either 0.5 U/g/day (cross hatched; rising to the right) or 1.0 U/g/day (cross hatched; rising to the left). On day 28, half of the rats from each group were killed while the other half were allowed to live for an additional 28 days with no further treatment before determining the percentage of cancellous bone surface lined with either osteoblasts (A) or osteoid (B). Data are expressed as mean ± SEM. *P < .005 when compared with either baseline or control values for both (A and B).

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