Effect of RU486 on Dex induction of Muc-1 expression on MM cells. S6B45 and RPMI 8226 MM cells were cultured in media alone or with Dex (10⁻⁸ mol/L) in the presence or absence of the glucocorticoid receptor antagonist RU486. (A) Changes in Muc-1 expression after culturing with Dex. (B) Changes in Muc-1 expression after culturing with both Dex and RU486. (C) Changes in isotype control MoAb staining in media alone, Dex alone, and Dex plus RU486 cultures. (a) Cells stained with isotype control MoAb. (b) Cells cultured with media alone and stained with the VU-4H5 MoAb. (c) Cells cultured with Dex and stained with the VU-4H5 MoAb. (d) Cells cultured with both Dex and RU486 and stained with the VU-4H5 MoAb.