(a and b) Histopathology from bm1 mice after transfer of C57BL/6 or MIP-1−/− B6 splenocytes. Bm1 mice that received splenocytes from C57BL/6 or MIP-1−/− B6 were killed 150 days after transfer. Tissues were prepared as indicated in the text. (a) shows (A and B) sections of liver from bm1 mouse that received MIP-1−/− B6 splenocytes compared with sections from an animal that received C57BL/6 splenocytes (D and E). Sections (A and B) and (D and E) represent two different magnifications of the same liver zone. (a, C) is a section of the lung of a bm1 mouse that received MIP-1−/− B6 splenocytes compared with (F) and (b, B) sections of lung from a bm1 mouse that received C57BL/6 splenocytes (figures are of the same section at different magnifications). Foci of inflammation are indicated by the arrows. The arrowheads indicate extravasation of material into the lungs of bm1 mice that received C57BL/6 splenocytes. (b, A) shows a crypt abscess in the gastrointestinal tract of a bm1 animal that received C57BL/6 splenocytes; these were not seen in animals that received MIP-1−/− splenocytes. The character of the mononuclear cell infiltrate in the liver is shown in (b, C).