Fig. 3.
Effect on thrombin generation of reducing vWF activity in plasma. (□) Control (normal PRP with 10 μg/mL rabbit IgG); (•) PRP preincubated with vWF antibody (10 μg/mL); (X) PRP preincubated with anti-vWF (10 μg/mL), three fibrin clots added at t = 90 s; (▴) preincubated with vWF antibody and 10 μmol/L ionomycin added at t = 10 s. (Inset) Thrombin generation in PPP. The reaction was triggered with PS/PC and Ca2+. (□) Control PPP with 10 μg/mL rabbit IgG; (•) PPP preincubated with anti-vWF (10 μg/mL).
