Decreased numbers of LC in skin after 4 weeks of VEGF infusion. Mice were treated with either PBS or VEGF for 7 or 27 days (VEGF infusion rate of 50 ng/h). The number of LC in the ventral trunk epidermis was counted as described in Materials and Methods. (A) Results of three independent experiments are presented. (B) Microphotograph of one representative experiment (original magnification × 50).