Neutralization of angiostatin-induced cytotoxicity in BME cells. BME cell monolayers were incubated for 72 hours in the presence of ehAst that had been preincubated with mouse MoAbs to kringles 1-3 (36E6) or kringle 5 (42B12) of human plasminogen. At the end of the incubation, endothelial cell cytotoxicity was assessed using the ethidium homodimer incorporation assay. Results are shown as the mean of duplicate samples.