Fig. 10.
Fig. 10. Functional analysis of −93/−84 binding site. Reporter assays were performed as in Fig 4. A construct containing a 2-bp mutation of the −93/−84 Sp1 (GGGGCGTGGC > GGTTCGTGGC) site, −124 XN2mt, displayed basal reporter activity. The −124 XN2mt/9/10 construct, which has the −93/−84 Sp1 site inserted 40 bp upstream in the −124 XN2mt construct, restores reporter activity to near wild-type levels.

Functional analysis of −93/−84 binding site. Reporter assays were performed as in Fig 4. A construct containing a 2-bp mutation of the −93/−84 Sp1 (GGGGCGTGGC > GGTTCGTGGC) site, −124 XN2mt, displayed basal reporter activity. The −124 XN2mt/9/10 construct, which has the −93/−84 Sp1 site inserted 40 bp upstream in the −124 XN2mt construct, restores reporter activity to near wild-type levels.

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