Histological sections of kidney, liver, heart, and brain from sph/sph,sph/sph→+/+^a, and +/+→+/+^a mice. (A, D, G, J, M, and P) WBB6F1-sph/sph. (B, E, H, K, N, and Q)sph/sph→+/+^a. (C, F, I, L, O, and R) +/+→+/+^a. (A through C) Kidney sections stained with H&E. (D through F) Identical kidney sections as in (A) through (C) stained with Gomori’s iron stain, which stains nonhemoglobin iron blue (D and E). (G through I) Liver sections stained with H&E. Clusters of extramedullary hematopoiesis (arrows) stain purple (G and H). (J through L) Identical regions of liver as shown in (G) through (I) stained with Gomori’s iron stain. (M through O) Heart sections stained with H&E showing the large atrioventricular valve. Note the presence of thrombi (indicated by arrows) in the valves of (M) and (N), whereas the valve of (O) is unobstructed. (P through R) Sagittal brain sections stained with H&E showing the cerebellar region of the brain. Note the degeneration (arrows) of portions of the cerebellum in both (P), in which about one third of the cerebellum is missing due to infarction, and (Q), in which an interior portion of the cerebellum is infarcted. Note also the lack of degeneration in (R).