Agonist activity of vMIP-II. Monocytes (mono), neutrophils (PMN), monocyte- and CD34-derived dendritic cells (mono-DC and CD34-DC, respectively) and Jurkat (J) cells (A) or Th1 and Th2 cultures (B) were tested for their ability to migrate in response to different concentrations of vMIP-II. (C) Northern blot analysis of CCR8 in Th1, Th2, Tc1 (Th1 CD8⁺), and Tc2 (Th2 CD8⁺) cultures.