Th2- and Tc2-skewed cytokine profile of CD4⁺ and CD8⁺ T-cell clones generated from the neoplastic skin of patients with KS. Clones were obtained from skin biopsy specimens, taken for diagnostic purpose from three HIV-infected patients with KS. As controls, cytokine production by T-cell clones generated under the same experimental conditions from skin biopsy specimens of one healthy volunteer, two patients with alopecia areata (AA), and three patients with atopic dermatitis (AD) was evaluated. Each symbol represents the amounts of IL-4 and IFN-γ produced by a single CD4⁺ (open squares) or CD8⁺ (closed circles) T-cell clone. Lines represent cutoff values (IFN-γ, 0.8 ng/mL; IL-4, 0.2 ng/mL), calculated as 5 SD over values found in cultures containing feeder cells alone.