Fig. 2.
Fig. 2. Alignment of hematopoietic Wnt genes. (A) Alignment of clone DV10 with Xenopus Wnt-2B(xWnt-2B; Genbank accession no. U66288) and humanWnt-13 (hWNT-13; Genbank accession no. Z71621). Amino acid identities are indicated by dots (•). The putative site of signal peptide cleavage based on hydrophobicity analysis is shown inxWnt-2B and DV10 by an arrow (). The homology between DV10 and hWnt-13 begins at the amino acid indicated by a diamond (◊). Amino acid numbering is shown on the right. Numbering begins with the initiation codon of DV10. (B) Alignment of clone DV12 with human Wnt-10B (hWnt-10B; Genbank accession no. U81787) and mouse Wnt-10B (mWnt-10B; Genbank accession no.U20658). (C) Alignment of the 5′ UTR of clone DV9 and humanWnt-5A (hWnt-5A; Genbank accession no. L20861). Numbering begins at the first nucleotide of the initiation codon. Homology between the two sequences begins at −41 and continues throughout the coding region. The 5′ UTRs for DV9 andhWnt-5A are 283 and 488 nucleotides, respectively.

Alignment of hematopoietic Wnt genes. (A) Alignment of clone DV10 with XenopusWnt-2B(xWnt-2B; Genbank accession no. U66288) and humanWnt-13 (hWNT-13; Genbank accession no. Z71621). Amino acid identities are indicated by dots (•). The putative site of signal peptide cleavage based on hydrophobicity analysis is shown inxWnt-2B and DV10 by an arrow (). The homology between DV10 and hWnt-13 begins at the amino acid indicated by a diamond (◊). Amino acid numbering is shown on the right. Numbering begins with the initiation codon of DV10. (B) Alignment of clone DV12 with human Wnt-10B (hWnt-10B; Genbank accession no. U81787) and mouse Wnt-10B (mWnt-10B; Genbank accession no.U20658). (C) Alignment of the 5′ UTR of clone DV9 and humanWnt-5A (hWnt-5A; Genbank accession no. L20861). Numbering begins at the first nucleotide of the initiation codon. Homology between the two sequences begins at −41 and continues throughout the coding region. The 5′ UTRs for DV9 andhWnt-5A are 283 and 488 nucleotides, respectively.

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