(A) Schematic representation of the effects of increasing apoptotic rate on the HSC dynamics, as predicted from the model proposed previously.191,192 The diagram shows the effect of administering the same dose of ⁸⁹Sr to W/W^v and S1/S1^d mice on the amplitude and the period of the oscillations. The dashed lines show the onset and the end of oscillations as the apoptotic rate increases. (B) Computer simulations of the normalized HSC efflux predicted191 for increasing apoptotic rates (from I to V). As the apoptotic rate is increased, the period of the oscillations increases and the amplitude increases and decreases consecutively.