Inhibition of the binding of activated MK to FGN. Guinea pig MK were activated by incubation with thrombin (0.5 U/mL) for 3 minutes at RT in the presence of varying concentrations of MK0852 or bitistatin. This was followed by the addition of hirudin (0.5 U/mL) to stop the reaction. Adhesion to FGN-coated coverslips and the analysis of the data were performed as described in the legend to Fig 2.