Pedigree of the two families with juvenile genetic hemochromatosis. Circles denote female family members and squares denote male family members. Solid symbols indicate probands. In family 2, the parents were consanguineous (first cousins). Each rectangle indicates the HLA-A locus and the presence (+) or absence (−) of the C282Y and H63D mutations. All individuals but the probands had normal body iron status. Some individuals in family 2 were heterozygous for β-thalassemia (β^Nβ^T), whereas the remaining ones had normal β-gene (β^Nβ^N).