8Cl-AD induces chromatin ladder formation. Five million MM.1S cells are treated for the indicated times with 3 μmol/L 8Cl-AD and low molecular weight DNA is obtained as described in Materials and Methods. Markers are the 123-bp DNA ladder (GIBCO BRL). DNA is fractionated through 1% agarose. HL-60 cells treated with 0.15 μmol/L camptothecin serve as a positive control for the DNA isolation protocol.