American Society of Hematology

Fig. 6.

$The effect of TPO on hematopoietic regeneration after 9 Gy TBI in mice. The mice were irradiated with three fractions (▾) of 3 Gy with 24-hour intervals. In the upper panel platelet regeneration is depicted, in the middle panel red blood cell regeneration is shown, and in the lower panel white blood cell regeneration is shown. (□), mice treated with three doses of 0.3 μg/mouse of mTPO IP 2 hours after each fraction of TBI; (┌), mice treated with 0.9 μg IP 2 hours after the last fraction of TBI (day 0); (▪), mice treated with 0.9 μg IP 2 hours before the first fraction of TBI; (○), control mice. Data are given as means ± SD, three mice per data point per group. The closed triangles (▴) are counts from mice treated with 30 μg of mTPO IP 2 hours before irradiation (n = 3).$

The effect of TPO on hematopoietic regeneration after 9 Gy TBI in mice. The mice were irradiated with three fractions (▾) of 3 Gy with 24-hour intervals. In the upper panel platelet regeneration is depicted, in the middle panel red blood cell regeneration is shown, and in the lower panel white blood cell regeneration is shown. (□), mice treated with three doses of 0.3 μg/mouse of mTPO IP 2 hours after each fraction of TBI; (┌), mice treated with 0.9 μg IP 2 hours after the last fraction of TBI (day 0); (▪), mice treated with 0.9 μg IP 2 hours before the first fraction of TBI; (○), control mice. Data are given as means ± SD, three mice per data point per group. The closed triangles (▴) are counts from mice treated with 30 μg of mTPO IP 2 hours before irradiation (n = 3).

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