EBV-LEUK1 cytogenetics and FISH analyses. (A) A partial karyotype of G-banded chromosomes 1, 8, and 10 from EBV-LEUK1 cells. The arrows indicate regions of chromosomal fusion. (B) Map of the YACs versus genetic markers from singly linked contigs WC-8.6 and WC-8.7. The relative size of the YACs and the spacing of the markers are not drawn to scale and are not precisely known. (C) Examples of FISH performed on EBV-LEUK1 cells with YAC probes from the human CEPH library. YACs 806_e_9, 857_g_5, and 971_c_5 appear yellow-green. The chromosome 8 centromeric probe appears red. YAC 911_f_10 and the 8q24 probe (MYC) appear red and yellow, respectively. DAPI-stained chromosomes are blue. White arrows highlight the split signal obtained with YAC 857_g_5, and yellow arrows highlight the lack of binding to 911_f_10.