Effect of ICI 182,780 on proliferation of MM cell lines and MM patient cells. ARH 77, OCI My-5, RPMI 8226, S6B45, and U266 MM cell lines (A) as well as purified MM cells from 2 patients (B) were cultured with 0.5 (▪), 5.0 (▨), and 50 (▧) μmol/L ICI 182,780 (ICI) for 48 hours. ³H-TdR uptake was compared with DNA synthesis of cells cultured in media alone. *P < .05. Mean CPM and SEM for media alone cultures were as follows: ARH (8,626 ± 2,511), OCI-My-5 (11,020 ± 965), RPMI 8226 (354,146 ± 10,439), S6B45 (99,331 ± 3,461), U266 (35,349 ± 4,037), MM patient no. 1 (2,121 ± 65), and MM patient no. 2 (14,059 ± 2,006).