(A) Effect of ISIS 2302 on the prothrombin (•), activated partial thromboplastin (PTT) (○), and thrombin times (▪) in normal pooled human plasma. (B) Detail of the plasma oligonucleotide concentration range that shows selective prolongation of the PTT (see text). Clotting times are expressed as the mean of triplicate determinations with error bars representing ±2 SD.