Intermittent upregulation of mTPO levels in serum, megakaryocyte number in bone marrow, and blood platelet levels in C57B1/6 mice by intermittent administration of dexamethasone (Dex) following one-time intravenous administration of the AdGRE.mTPO vector. After administration of AdGRE.mTPO (5 × 108 pfu), dexamethasone was administered intraperitoneally (50 μg/dose) on 3 consecutive days starting at days 1, 22, and 43. (A) The mTPO concentration in serum evaluated before and 4 to 64 days after vector administration. Shown are data for mTPO level in serum with dexamethasone (•) and without dexamethasone (○). (B) The number of megakaryocytes in bone marrow before and 4 to 64 days following vector administration. Shown are data for megakaryocytes with dexamethasone (•) and without dexamethasone (○). (C) Platelet levels before and 4 to 64 days after vector administration. Shown are data for platelet levels with dexamethasone (•) and without dexamethasone (○). The data are presented as mean ± SE of three independent experiments.
