Evaluation of eosinophil recruitment in P-selectin/ICAM-1–deficient double-mutant mice. Ragweed-sensitized mice (P-selectin/ICAM-1–deficient or control wild-type mice) were challenged with an intraperitoneal injection of ragweed. Forty-eight hours later, the percentage of transmigrated peritoneal eosinophils was assessed by light microscopy. P-selectin/ICAM-1–deficient double-mutant mice developed significantly less peritoneal eosinophilia compared with control wild-type mice after allergen (P = .01).