HIV-1–induced depletion of mature and immature thymocyte subsets in the SCID-hu Thy/Liv mouse. Depletion of thymocyte subsets by HIV-1 strains NL4-3, JD, and PD was assessed at day 9 to 14 after infection. Cell numbers are expressed as percentages of values from mock-infected control grafts (Mean ± SEM). Data for NL4-3 summarize 10 separate experiments with 57 animals; data for JD summarize 5 experiments with 26 animals; and data for PD summarize 2 experiments with 10 animals. Each experiment used SCID-hu mouse cohorts made with fetal tissue from separate donors. *P < .01 (unpairedt-test) for difference between depletion of CD3⁻CD4⁺CD8⁻ and CD3⁺CD4⁺CD8⁻ cells. (□) Total thymocytes; (▨) CD3⁺CD4⁺CD8⁻; (▪) CD3⁻CD4⁺CD8⁻.