Fig. 5.
![Growth of human MM cells within SCID-hu mice triggers human IL-6 secretion. RPMI-8226 MM cells (1 × 104) were injected directly into the marrow cavity of the left human fetal bone implant in SCID-hu mice, and secretion of human IL-6 in mouse sera at 4, 8, and 12 weeks was determined by ELISA (A). ARH-77, OCI-My5, U-266, and RPMI-8226 MM cells ([▧] 1 × 104 MM cells; and [] 5 × 104 MM cells) were also injected directly into the marrow cavity of the left human fetal bone implant in SCID-hu mice, and the levels of human IL-6 in sera samples taken from these mice 12 weeks later were measured by ELISA (B).](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/90/2/10.1182_blood.v90.2.754/4/bl_0023f5a.jpeg?Expires=1720837380&Signature=FtA6YfC11FCovIqNvEWlreR2w63eGR4HlPz3IopECKyi4wBXoVnV5LfWPtFtBCFW84s6CO8JtLFHLSzGthMG3cOqm1zGh78T6O6uHZqxAu75PzuQ1oxYVfgd3imZ-yMrPhcnUTvhYjgjvyyygY-PXuzgGTAfDwTH~2hSXuBU7-LAy0-Pq08IsS8FS40mdMvzGXJpaUmvZaghiAUuPKWmTXdwbwwR4tV0p9xNFyDZSNzgCUB2wJTBV9Ys-Zh3MKeQq5OC7dsspssjsIAP-K78jLqxSZk76hnaFmx~oQrMozTCs5fDwMC~8Xj0bszIebKulz9KMXwlu4YRsJoIJ1F6sA__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Growth of human MM cells within SCID-hu mice triggers human IL-6 secretion. RPMI-8226 MM cells (1 × 104) were injected directly into the marrow cavity of the left human fetal bone implant in SCID-hu mice, and secretion of human IL-6 in mouse sera at 4, 8, and 12 weeks was determined by ELISA (A). ARH-77, OCI-My5, U-266, and RPMI-8226 MM cells ([▧] 1 × 104 MM cells; and [] 5 × 104 MM cells) were also injected directly into the marrow cavity of the left human fetal bone implant in SCID-hu mice, and the levels of human IL-6 in sera samples taken from these mice 12 weeks later were measured by ELISA (B).
