Amino acid sequence of LMP-1 in the sequenced EBV strains compared to B95.8³⁴ and CAO.¹¹ The EBV strains are designated Groups A through D according to the pattern of mutations. Many of the isolates contained occasional additional amino acid mutations (data not shown). For Groups A through D and CAO only differences compared to B95.8 are shown. The positions of the carboxy-terminal activation region-1 (CTAR-1) and CTAR-2 are indicated by (__); deletions are indicated by (***); additional 33-bp repeats compared to B95.8 by (///); amino acids located within the plasma-membrane by (mmm); in the intra-cytoplasmatic part of the loops by (” ” ”); and on the outer surface by (xxx). The number of 33-bp repeats varied within Groups B through D. A representative repeat region is shown for each group.