The nucleotide sequence of LMP-1 in the EBV strain B95.8 compared with our sequencing data for wild-type isolates, designated Groups A through D according to the pattern of mutations, and with CAO and Raji11 for comparison. Most of the isolates contained occasional additional single base mutations (see Table 1). For Groups A through D, CAO and Raji only differences compared to B95.8 are shown. Nucleotide numbering is according to Baer et al.34 Deletions are indicated with (***); the repeat region is indicated with (- - -).The number of 33-bp repeats varied within Groups B through D. A representative repeat region is shown for each group.