Fig. 1.
Fig. 1. Influence of rCD44v4-v7 on the distribution of BMC in lymphoid organs of the lethally irradiated host. Lethally irradiated (850 R) C57BL/6 mice received 5 × 106 51Cr-labeled BMC from NTG or rCD44v4-v7 TG C57BL/6 mice together with 200 μg control (3-9) or anti-rCD44v6 (1.1ASML) F(ab′)2 fragments, IV. Injections of F(ab′)2 fragments were repeated after 3 days. Animals were bled from the retroorbital sinus and were killed after 1, 8, 24, 48, 72, and 96 hours. Bone marrow, thymus, and spleen were excised and weighed. Radioactivity was determined in a γ-counter and the radioactivity per organ was calculated. Mean cpm ± SD are shown; significant differences (P ≤ .01) between cpm in mice receiving TG BMC and control F(ab′)2 or anti-rCD44v6 F(ab′)2 are indicated by an asterisk.

Influence of rCD44v4-v7 on the distribution of BMC in lymphoid organs of the lethally irradiated host. Lethally irradiated (850 R) C57BL/6 mice received 5 × 106 51Cr-labeled BMC from NTG or rCD44v4-v7 TG C57BL/6 mice together with 200 μg control (3-9) or anti-rCD44v6 (1.1ASML) F(ab′)2 fragments, IV. Injections of F(ab′)2 fragments were repeated after 3 days. Animals were bled from the retroorbital sinus and were killed after 1, 8, 24, 48, 72, and 96 hours. Bone marrow, thymus, and spleen were excised and weighed. Radioactivity was determined in a γ-counter and the radioactivity per organ was calculated. Mean cpm ± SD are shown; significant differences (P ≤ .01) between cpm in mice receiving TG BMC and control F(ab′)2 or anti-rCD44v6 F(ab′)2 are indicated by an asterisk.

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