Fig. 4.
![Fig. 4. Cyotoxicity of recombinant toxins towards normal bone marrow cells. Normal marrow mononuclear cells (106/0.1 mL well) were incubated with DT388–GM-CSF (▵) or GM-CSF–PE38KDEL (○) for 60 hours and pulsed with [3H]-leucine. In (A), the cells were incubated in parallel with the negative control molecules PE38KDEL (•) or DT388-IL2 (▴). In (B), the cells were also incubated with DT388–GM-CSF (▪) or GM-CSF–PE38KDEL (□) in the presence of 20 ng/mL of GM-CSF.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/90/1/10.1182_blood.v90.1.252/5/bl_0029f4.jpeg?Expires=1722792338&Signature=KviEkP0wjL3PPcKKYMbVuYOwlWWNzMwvWG8pkegGOzc21ftSXV~BH9frWRghIkoCB-0snefIyU3I85PgvSzBkjvmd1MVoaxDZOKaatazzdWsDncL92Q9Xh2VVA721dq8~Cu4TvJhDtsPfTidEYIGY-ZAxawXSaZsLrIj-5~h4l2-3UqZXYj17rhSf5~K8~5IMCPXkTdoh8P3qxF-WqWOssYAL8fqqQYSFxfvYNsDWkZRgwyTS97q5Un50-T4W3yq~AKDVKo6KQC92wUyI4ivgzxDt4v1dZKWsxC7y03ZpzE53HjxOHFjanhh~w-fv3Ku4IXU4inFT397tF6EdMGOcg__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Cyotoxicity of recombinant toxins towards normal bone marrow cells. Normal marrow mononuclear cells (106/0.1 mL well) were incubated with DT388–GM-CSF (▵) or GM-CSF–PE38KDEL (○) for 60 hours and pulsed with [3H]-leucine. In (A), the cells were incubated in parallel with the negative control molecules PE38KDEL (•) or DT388-IL2 (▴). In (B), the cells were also incubated with DT388–GM-CSF (▪) or GM-CSF–PE38KDEL (□) in the presence of 20 ng/mL of GM-CSF.
