Fig. 4.
Effect of PF4 on the chemosensitivity of normal bone marrow cells in response to DNR (A) and ETP (B). Cells (2 × 106/mL) were preincubated with or without PF4 (5 μg/mL) in a volume of 100 μL per well in 24-well culture plates for 48 hours. DNR and ETP at various concentrations were then added respectively for an additional 24 hours. Cell viability was measured with an MTT assay. One hundred percent corresponds to the number of viable cells in drug- and PF4-free control samples after incubation for 3 days. There was a statistically significant difference between the drug alone and the drug plus PF4 for every concentration point (P < .05).
