Transduction of HSCs with long-term reconstitution activity in the SCID-hu bone mice. MA2.1⁺ donor CD34⁺ cells were transduced with LMiLy and injected into MA2.1⁻ host bone fragments implanted in SCID mice. Donor cells were assayed for Lyt2 expression (A) and coexpression of CD14 and Lyt2 at 8 weeks posttransplantation (B). Control bone fragments were from irradiated SCID-hu bone mice not injected with any donor cells.