Fig. 6.
![Fig. 6. Fit of data obtained from in vitro cell assays to a mathematic model describing antibody-mediated receptor dimerization. Determination of KD by BIAcore analysis showed a value of ∼84 nmol/L. Baseline values for proliferation ([3H]thymidine incorporation in the absence of MoAb34) were subtracted. (A) Proliferation of BaF3/EPO-R cells; (B) proliferation of UT-7/EPO cells; (C) differentiation of CD34+ cells. The mean number of colonies obtained in the 2 counts of experiment 2 (Table 2) was used.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/89/2/10.1182_blood.v89.2.473/4/bl_0016f6.jpeg?Expires=1722721289&Signature=bVkEr6W9lZ7WmIAzq~o4AxZaSIJwHgiCiaN4m1TTCx0mghlf3Ir6cTUehudaoYs-4ytE0qaAiiY4d-BzOmHpCcU18H1auSWRwPdLX8~gRE7-zOx4QHgUfRwNAqZFMziQIr3SWZZYXcXQmLzSCTEEdWwbTCMnk1Xm~HKr5taUqEufyMUh4VnDtT5PzoECeRPZMrcu8~I20tmJQHCUPW~2fsCQTiVwTbPggnxmWNuxgjBRYVPs0tVIrpd-rX-7OLQwLAqyoB2zEmHpK0M42xROQYFp17bGSSTss70Xl1vvqQtVXn879cfBgkAFPKOLvreTmOKK8PBbplbp3K2I2w1bzA__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Fit of data obtained from in vitro cell assays to a mathematic model describing antibody-mediated receptor dimerization. Determination of KD by BIAcore analysis showed a value of ∼84 nmol/L. Baseline values for proliferation ([3H]thymidine incorporation in the absence of MoAb34) were subtracted. (A) Proliferation of BaF3/EPO-R cells; (B) proliferation of UT-7/EPO cells; (C) differentiation of CD34+ cells. The mean number of colonies obtained in the 2 counts of experiment 2 (Table 2) was used.
