The threshold effect of progenitor cell dose on hematopoietic reconstitution after mobilized blood cell autotransplants in the authors' institution. In (A) and (B), patients were categorized into those receiving <15, 15 to 49.9, and ≥50 × 104 CFU-GM/kg BW. In (A) the probability of reaching 0.5 × 109 neutrophils/L (N500) for each of these three categories was denoted by the lines - - -, — , ⋅⋅⋅, respectively. The number of patients in the three categories were 47, 142, and 88, respectively. The differences between the three categories were significant (P < .0001, log-rank test). In (B) the probability of reaching 50 × 109 platelets/L (P50) for each of these three categories was denoted by the lines - - -, — , ⋅⋅⋅, respectively. The number of patients in the three categories were 45, 131, and 86, respectively. The differences between the three categories were significant (P < .0001, log-rank test).
In (C) and (D) patients were categorized into those receiving <1.5, 1.5 to 4.9, and ≥5 × 106 CD34+ cells/kg BW. The number of patients in these three categories were 39, 53, and 31, respectively. In (C) the probability of reaching 0.5 × 109 neutrophils/L (N500) for each of these three categories was denoted by the lines - - -, — , ⋅⋅⋅, respectively. The differences between the three categories were not significant (P = .29, log-rank test). In (D) the probability of reaching 50 × 109 platelets/L (P50) for each of these three categories was denoted by the lines - - -, — , ⋅⋅⋅, respectively. The number of patients in these three categories were 35, 49, and 27, respectively. The differences between the three categories were significant (P = .0052, log-rank test).
