Fig. 1.
![Fig. 1. The src kinase activity in fibroblasts exposed to hypoxia. Transformed embryonic murine fibroblasts, described in the Methods, were exposed to different oxygen tensions (21%, 1%, 0.1 %, and anoxia [0%]) for 30, 60, and 90 minutes. The results are expressed as the ratio of activity to that of normoxic cells cultured in parallel and are the means ± SE of 3 (30 and 90 minutes) or 5 (60 minutes) independent experiments. An increase in activity was seen when cells were exposed to severe hypoxia (0.1% oxygen or anoxia), but not 1% oxygen; significantly different from normoxic activity, *P < .05.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/89/2/10.1182_blood.v89.2.503/4/bl_0014f1.jpeg?Expires=1722413639&Signature=sSDdQ~0tCj5B9O1H32IzDtHx1LkIX4BnBvpjgwqJw4CVr3ZEe8S1fGAbCx8mMHEJuFs8Sd7d8Yrr2IZn08dZToTj21trod-ffwrD3G~8ZjeRqe4zOEh62CdngmIQnP07P0XxMt1jOKCj4mqeEGVNWehekwFVqKOLjBwzxICiBwXyd6ZAjlD3fRAgyWfD~7f3mqQoMqI3lVKvskqDD1I3PjkPDiO~R6N8nymuO2uNsZoG9ryVUOGW4WZ3VHys7GtpCzJlruWw4DPAGDlPtRvfFHGpMfAXw8EKcwA-ZcbjswbKKmu2UjW6z3FH9YjuvsKJSLXTOSs~aAt~hMxBoy49Qg__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
The src kinase activity in fibroblasts exposed to hypoxia. Transformed embryonic murine fibroblasts, described in the Methods, were exposed to different oxygen tensions (21%, 1%, 0.1 %, and anoxia [0%]) for 30, 60, and 90 minutes. The results are expressed as the ratio of activity to that of normoxic cells cultured in parallel and are the means ± SE of 3 (30 and 90 minutes) or 5 (60 minutes) independent experiments. An increase in activity was seen when cells were exposed to severe hypoxia (0.1% oxygen or anoxia), but not 1% oxygen; significantly different from normoxic activity, *P < .05.
