(A) PFS of 59 patients without p53 abnormalities (*) is compared with that of 16 patients with abnormalities (○). Patients without abnormalities progressed in a median of 8.2 months, as compared with 2.1 months for patients with abnormalities. (B) OS of 59 patients without p53 abnormalities (*) is compared with that of 16 patients with abnormalities (○). Patients without abnormalities died in a median of 21.5 months, as compared with 11.7 months for patients with abnormalities.