TAP2-deficient CANK cell lines display specific enhanced migration ability to CCR2 ligands. Migration assays were performed, as described in “Materials and methods.” Dose-dependent migration capacity of healthy donor (▪) CANK cell lines and TAP-2–deficient CANK cells (♦) to various concentrations of MCP-1 (A), MCP-2 (B), MCP-3 (C), and IP-10 (D) was examined. In each experiment, the migration index of TAP-2–deficient CANK cells from all wells with a certain chemokine concentration were averaged and presented in the graph. Healthy-donor–derived CANK-cell migration indeces (obtained from 7 healthy donors and the patient's mother) were averaged and grouped similarly. **P < .01 by Student t test. Error bars indicate SD. Results are of 1 representative experiment of 3 experiments performed on CANK cell lines generated on 3 independent occasions from each donor.