Figure 3.
Figure 3. Pulmonary histopathologic analysis of ProcrLox and Procr +/+ mice after high-dose factor Xa/PCPS administration. Immunohistochemical detection of fibrin deposition in the lung of (A) Procr +/+ and (B) ProcrLox mice. Red alkaline phosphatase reaction product identifies fibrin/fibrinogen antigens. ProcrLox mice showed much more intravascular fibrin deposition than Procr +/+ mice. Hematoxylin and eosin (H&E) staining showed more and larger intravascular thrombi in the pulmonary vessels in (D) ProcrLox mice than in (C) Procr +/+ mice. (C-D) Arrows indicate thrombi and red staining indicates red blood cells trapped in the vessels. Slides are representative of 4 mice per group. Fluorescence quantitation shows that the AFI of fibrin/fibrinogen staining is more in ProcrLox mice than wild-type mice (1342 ± 668 vs 388 ± 205, n = 4, P < .05). Original magnification for all panels, × 100.

Pulmonary histopathologic analysis of ProcrLox and Procr+/+ mice after high-dose factor Xa/PCPS administration. Immunohistochemical detection of fibrin deposition in the lung of (A) Procr+/+ and (B) ProcrLox mice. Red alkaline phosphatase reaction product identifies fibrin/fibrinogen antigens. ProcrLox mice showed much more intravascular fibrin deposition than Procr+/+ mice. Hematoxylin and eosin (H&E) staining showed more and larger intravascular thrombi in the pulmonary vessels in (D) ProcrLox mice than in (C) Procr+/+ mice. (C-D) Arrows indicate thrombi and red staining indicates red blood cells trapped in the vessels. Slides are representative of 4 mice per group. Fluorescence quantitation shows that the AFI of fibrin/fibrinogen staining is more in ProcrLox mice than wild-type mice (1342 ± 668 vs 388 ± 205, n = 4, P < .05). Original magnification for all panels, × 100.

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