![Figure 2. WKY rats immunized with hMPO develop focal necrotizing crescentic glomerulonephritis and pulmonary hemorrhage. (A) No histologic abnormalities in a rat immunized with HSA (Periodic acid Schiff; UplanApo 40×/0.85 NA); (B) severe crescentic glomerulonephritis (arrows) in a rat immunized with hMPO (Periodic acid Schiff; UplanApo 10×/0.40 NA); (C) tubulo-interstitial nephritis with red cell cast (arrow) in a rat immunized with hMPO (hematoxylin and eosin [H&E]; UplanApo 10×/0.40 NA); (D) focal glomerular necrosis, with an adjacent glomerulus showing normal architecture in a rat immunized with hMPO (H&E; UplanApo 20×/0.70 NA); (E) focal necrotizing lesion with early crescent formation (arrow) in a rat immunized with hMPO (H&E; UplanApo 40×/0.85 NA); (F) circumferential glomerular crescent (arrow) in a rat immunized with hMPO (H&E; UplanApo 10×/0.40 NA); (G) normal lung architecture in a rat immunized with HSA (H&E; UplanApo 10×/0.40 NA). (H) Pulmonary vasculitis (arrow) in a rat immunized with hMPO (H&E; UplanApo 20×/0.70 NA); (I) pulmonary hemorrhage in a rat immunized with hMPO, with extensive blood in the alveolar spaces (H&E; UplanApo 10×/0.40 NA).](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/106/6/10.1182_blood-2005-03-0921/6/zh80180584160002.jpeg?Expires=1724246100&Signature=E2HwD~8mAgld8mP1mtQcA8ja-dvVobKIlvbo~JYyy3GFTaQNikDuQbrYI84qD1BwEw8DP~xkOgDTj~KLRMpYVKOwUJOkWLnQWsF~j1nare-2MVUEPkgCYEFMdaQ5e9n5zS2eTpLscvZJ2OrZFyor7KQssCK-u87bLNDqqgGR6TCWJ3jWVden9KInQzrnTujVGjR-PEaXEGNWq-f-uIzkZ-yM0~pyal85gQBHjtr5do~69b2SPzVEoHcWD1ettD90p6Bi3C0a0pJ1M0VoGDBMhCx6FVOZsfiQKCFgpmuAhs-g5wzLJwug~5fFOzJRjN258rwiQNuUHV5kqjrSr3j7SQ__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
WKY rats immunized with hMPO develop focal necrotizing crescentic glomerulonephritis and pulmonary hemorrhage. (A) No histologic abnormalities in a rat immunized with HSA (Periodic acid Schiff; UplanApo 40×/0.85 NA); (B) severe crescentic glomerulonephritis (arrows) in a rat immunized with hMPO (Periodic acid Schiff; UplanApo 10×/0.40 NA); (C) tubulo-interstitial nephritis with red cell cast (arrow) in a rat immunized with hMPO (hematoxylin and eosin [H&E]; UplanApo 10×/0.40 NA); (D) focal glomerular necrosis, with an adjacent glomerulus showing normal architecture in a rat immunized with hMPO (H&E; UplanApo 20×/0.70 NA); (E) focal necrotizing lesion with early crescent formation (arrow) in a rat immunized with hMPO (H&E; UplanApo 40×/0.85 NA); (F) circumferential glomerular crescent (arrow) in a rat immunized with hMPO (H&E; UplanApo 10×/0.40 NA); (G) normal lung architecture in a rat immunized with HSA (H&E; UplanApo 10×/0.40 NA). (H) Pulmonary vasculitis (arrow) in a rat immunized with hMPO (H&E; UplanApo 20×/0.70 NA); (I) pulmonary hemorrhage in a rat immunized with hMPO, with extensive blood in the alveolar spaces (H&E; UplanApo 10×/0.40 NA).
