Analysis of the cathepsin C promoter. (A) Diagram of SIRV-GFP reporter carrying the cathepsin C promoter. Sequences and mutations of element-1 and element-2 are shown on right. The numbers indicate the nucleotide positions relative to the start codon. (B) Cathepsin C promoter activity in live cells monitored by flow cytometry. The promoter activity was analyzed as in Figure 4B. Values represent fold changes in MFI caused by estradiol treatment.