(in Harousseau et al). Relationship of spiked gene expression and cluster-defined subgroups.

Myeloma oncogenes hyperactivated by 14q32 translocations can be visualized with microarray. Gene spikes are non-randomly distributed among unsupervised hierarchical cluster-defined myeloma subgroups. The quantitative measure of mRNA expression, the so-called Affymetrix signal, in each of 221 myeloma cases is indicated on the vertical axis. The gene expression profiling (GEP)-defined groups are indicated. Unlike the MMSET and CCND1 spikes, MAF and MAFB spikes are not linked to one single group; however, this is likely due to the small numbers of cases as the trend was for both spikes to be in Group III.